Bayer, Peter, Gatenby, Robert A., McDonald, Patricia, Duckett, Derek, Stankova, Katerina and Brown, Joel Steven (2022) Coordination games in cancer. Plos One, vol. 17 (n° 1).

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Identification Number : 10.1371/journal.pone.0261578


We propose a model of cancer initiation and progression where tumor growth is modulated by an evolutionary coordination game. Evolutionary games of cancer are widely used to model frequency-dependent cell interactions with the most studied games being the Prisoner’s Dilemma and public goods games. Coordination games, by their more obscure and less evocative nature, are left understudied, despite the fact that, as we argue, they offer great potential in understanding and treating cancer. In this paper we present the conditions under which coordination games between cancer cells evolve, we propose aspects of cancer that can be modeled as results of coordination games, and explore the ways through which coordination games of cancer can be exploited for therapy.

Item Type: Article
Language: English
Date: 2022
Refereed: Yes
Divisions: TSE-R (Toulouse)
Site: UT1
Date Deposited: 13 Apr 2023 09:26
Last Modified: 18 Apr 2024 11:33
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