eprintid: 50769 rev_number: 19 eprint_status: archive userid: 1482 importid: 105 dir: disk0/00/05/07/69 datestamp: 2025-04-08 09:54:25 lastmod: 2025-04-16 08:08:54 status_changed: 2025-04-16 08:08:54 type: article metadata_visibility: show creators_name: Bardey, David creators_name: De Donder, Philippe creators_name: Zaporozhets, Vera creators_id: david.bardey@tse-fr.eu creators_id: philippe.dedonder@tse-fr.eu creators_id: vera.zaporozhets@tse-fr.eu creators_idrefppn: 06064754X creators_idrefppn: 199756120 creators_idrefppn: 241587085 creators_halaffid: 1002422 creators_halaffid: 1002422;441569;81148 creators_halaffid: 1002422;577435;81148 title: The Health Technology Assessment Approach of the Economic Value of Diagnostic Tests : A Literature Review ispublished: pub subjects: subjects_ECO abstract: We review the medico-economic literature assessing the economic value of diagnostic and prognostic tests, with a focus on innovative and, more specifically, companion tests. Our analysis begins with a summary of systematic reviews that provide a descriptive synthesis of existing findings rather than conducting quantitative meta-analyses. These reviews reveal no consistent evidence that such tests outperform traditional approaches, such as pharmaceutical interventions. However, the cost-effectiveness of these tests, often measured in cost per QALY (Quality-Adjusted Life Year) gained, exhibits considerable heterogeneity. Notably, some genetic testing procedures may demonstrate superior performance compared to non-genetic alternatives. We then examine the economic implications of imperfect test features, exploring strategies to optimize their accuracy levels and integrating these considerations into the assessment of their economic value. Lastly, we review recent methodological and empirical studies employing these approaches, highlighting advancements in evaluating the economic impact of diagnostic and prognostic tests. date: 2025-03-23 date_type: published publisher: Springer Nature Switzerland AG id_number: 10.1007/s44250-025-00196-9 official_url: http://tse-fr.eu/pub/130496 faculty: tse divisions: tse keywords: Genetic tests keywords: Innovative tests keywords: Companion tests keywords: Health Technology Assessment (HTA) keywords: Personalized medicine keywords: Receiver-operator (ROC) curve keywords: Incremental cost-effectiveness ration (ICER) language: en has_fulltext: TRUE doi: 10.1007/s44250-025-00196-9 subjectsJEL: JEL_H51 subjectsJEL: JEL_I18 subjectsJEL: JEL_J17 view_date_year: 2025 full_text_status: public publication: Discover Health Systems volume: Vol. 4 number: N° 26 place_of_pub: Cham, CH refereed: TRUE issn: 2731-7501 oai_identifier: oai:tse-fr.eu:130496 harvester_local_overwrite: number harvester_local_overwrite: volume harvester_local_overwrite: date harvester_local_overwrite: issn harvester_local_overwrite: pending harvester_local_overwrite: creators_idrefppn harvester_local_overwrite: creators_halaffid harvester_local_overwrite: publisher harvester_local_overwrite: id_number harvester_local_overwrite: creators_id harvester_local_overwrite: place_of_pub harvester_local_overwrite: hal_id harvester_local_overwrite: hal_version harvester_local_overwrite: hal_url harvester_local_overwrite: hal_passwd oai_lastmod: 2025-04-10T07:02:04Z oai_set: tse site: ut1 hal_id: hal-05024927 hal_passwd: tko@92x0 hal_version: 1 hal_url: https://hal.science/hal-05024927 citation: Bardey, DavidIdRef , De Donder, PhilippeIdRef and Zaporozhets, VeraIdRef (2025) The Health Technology Assessment Approach of the Economic Value of Diagnostic Tests : A Literature Review. Discover Health Systems, Vol. 4 (N° 26). document_url: https://publications.ut-capitole.fr/id/eprint/50769/1/bardey_50769.pdf