@article{publications48161,
          volume = {vol. 9},
          number = {n? 32},
           month = {August},
          author = {Benjamin C. Trumble and Mia Charifson and Thomas S. Kraft and Angela Garcia and Daniel Cummings and Paul L. Hooper and Amanda J. Lea and Daniel Eid Rodriguez and Stephanie Koebele and Kenneth Buetow and Bret A. Beheim and Riana Minocher and Maguin Gutierrez Cayuba and Gregory Thomas and Margaret Gatz and Jonathan Stieglitz and Caleb Ellicott Finch and Hillard Kaplan and Michael Gurven},
         address = {Washington},
           title = {Apolipoprotein-{\ensuremath{\epsilon}}4 is associated with higher fecundity in a natural fertility population},
       publisher = {American Association for the Advancement of Science},
            year = {2023},
         journal = {Science Advances},
           pages = {1--9},
             url = {https://publications.ut-capitole.fr/id/eprint/48161/},
        abstract = {In many populations, the apolipoprotein-{\ensuremath{\epsilon}}4 (APOE-{\ensuremath{\epsilon}}4) allele increases the risk for several chronic diseases of aging, including dementia and cardiovascular disease; despite these harmful effects at later ages, the APOE-{\ensuremath{\epsilon}}4 allele remains prevalent. We assess the impact of APOE-{\ensuremath{\epsilon}}4 on fertility and its proximate determinants (age at first reproduction, interbirth interval) among the Tsimane, a natural fertility population of forager-horticulturalists. Among 795 women aged 13 to 90 (20\% APOE-{\ensuremath{\epsilon}}4 carriers), those with at least one APOE-{\ensuremath{\epsilon}}4 allele had 0.3 to 0.5 more children than ({\ensuremath{\epsilon}}3/{\ensuremath{\epsilon}}3) homozygotes, while those with two APOE-{\ensuremath{\epsilon}}4 alleles gave birth to 1.4 to 2.1 more children. APOE-{\ensuremath{\epsilon}}4 carriers achieve higher fertility by beginning reproduction 0.8 years earlier and having a 0.23-year shorter interbirth interval. Our findings add to a growing body of literature suggesting a need for studies of populations living in ancestrally relevant environments to assess how alleles that are deleterious in sedentary urban environments may have been maintained by selection throughout human evolutionary history.}
}