eprintid: 46983 rev_number: 11 eprint_status: archive userid: 1482 importid: 105 dir: disk0/00/04/69/83 datestamp: 2023-03-08 10:42:12 lastmod: 2023-10-27 07:55:20 status_changed: 2023-10-27 07:55:20 type: monograph metadata_visibility: show creators_name: Avila, Piret creators_name: Lehmann, Laurent creators_id: piret.avila@gmail.com creators_id: Laurent.Lehmann@unil.ch creators_idrefppn: 269118519 creators_idrefppn: 194696510 title: Life history and mutation rate joint evolution ispublished: pub subjects: subjects_ECO abstract: The cost of germline maintenance gives rise to a trade-off between lowering the deleterious muta-tion rate and investing in life history functions. Therefore, life history and the mutation rate evolve jointly, but this coevolution is not well understood. We develop a mathematical model to analyse the evolution of resource allocation traits affecting simultaneously life history and the deleterious mutation rate. First, we show that the invasion fitness of such resource allocation traits can be approximated by the basic reproductive number of the least-loaded class; the expected lifetime pro-duction of offspring without deleterious mutations born to individuals without deleterious mutations. Second, we apply the model to investigate (i) the joint evolution of reproductive effort and germline maintenance and (ii) the joint evolution of age-at-maturity and germline maintenance. This analysis provides two biological predictions. First, under higher exposure to environmental mutagens (e.g. oxygen), selection favours higher allocation to germline maintenance at the expense of life history. Second, when exposure to environmental mutagens is higher, life histories tend to be faster with individuals having shorter life spans and smaller body sizes at maturity. Our results suggest that mutation accumulation via the cost of germline maintenance is a major force shaping life-history traits. date: 2023-03 date_type: published publisher: IAST Working Paper official_url: http://iast.fr/pub/127935 faculty: tse divisions: tse keywords: life-history evolution keywords: mutation accumulation keywords: adaptive dynamics keywords: cost of fidelity keywords: mutation rate evolution language: en has_fulltext: TRUE view_date_year: 2023 full_text_status: public monograph_type: working_paper series: IAST Working Paper volume: 23-151 place_of_pub: Toulouse pages: 47 institution: Université Toulouse Capitole department: Institute for Advanced Study in Toulouse book_title: IAST Working Paper oai_identifier: oai:tse-fr.eu:127935 harvester_local_overwrite: creators_idrefppn harvester_local_overwrite: pending harvester_local_overwrite: department harvester_local_overwrite: pages harvester_local_overwrite: place_of_pub harvester_local_overwrite: institution harvester_local_overwrite: creators_id oai_lastmod: 2023-09-18T09:44:12Z oai_set: tse site: ut1 citation: Avila, Piret and Lehmann, Laurent (2023) Life history and mutation rate joint evolution. IAST Working Paper, n. 23-151, Toulouse document_url: https://publications.ut-capitole.fr/id/eprint/46983/1/wp_iast_151.pdf