eprintid: 43846 rev_number: 14 eprint_status: archive userid: 1482 importid: 105 dir: disk0/00/04/38/46 datestamp: 2021-10-04 12:30:22 lastmod: 2023-09-08 08:22:18 status_changed: 2023-06-08 07:14:32 type: article metadata_visibility: show creators_name: Garcia, Angela creators_name: Finch, Caleb Ellicott creators_name: Gatz, Margaret creators_name: Kraft, Thomas S. creators_name: Eid Rodriguez, Daniel creators_name: Cummings, Daniel creators_name: Charifson, Mia creators_name: Buetow, Kenneth creators_name: Beheim, Bret A. creators_name: Allayee, Hooman creators_name: Thomas, Gregory creators_name: Stieglitz, Jonathan creators_name: Gurven, Michael creators_name: Kaplan, Hillard creators_name: Trumble, Benjamin C. creators_idrefppn: 060256559 creators_idrefppn: 241587034 creators_affiliation: Institute for Advanced Study in Toulouse; Université Toulouse 1 Capitole creators_halaffid: 506116;81148 title: APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population ispublished: pub subjects: subjects_ECO abstract: In post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pathogen and energy-limited contexts, the APOE4 allele confers benefits by reducing innate inflammation when uninfected, while maintaining higher lipid levels that buffer costs of immune activation during infection. Among Tsimane forager-farmers of Bolivia (N = 1266, 50% female), APOE4 is associated with 30% lower C-reactive protein, and higher total cholesterol and oxidized LDL. Blood lipids were either not associated, or negatively associated with inflammatory biomarkers, except for associations of oxidized LDL and inflammation which were limited to obese adults. Further, APOE4 carriers maintain higher levels of total and LDL cholesterol at low body mass indices (BMIs). These results suggest that the relationship between APOE4 and lipids may be beneficial for pathogen-driven immune responses and unlikely to increase cardiovascular risk in an active subsistence population. date: 2021-09-29 date_type: published publisher: eLife Sciences Publications id_number: 10.7554/eLife.68231 official_url: http://iast.fr/pub/126075 faculty: tse divisions: tse language: en has_fulltext: TRUE doi: 10.7554/eLife.68231 physical_desc: 20 view_date_year: 2021 full_text_status: public publication: eLife number: 10:e68231 pagerange: 1-20 refereed: TRUE issn: 2050-084X oai_identifier: oai:tse-fr.eu:126075 harvester_local_overwrite: date harvester_local_overwrite: issn harvester_local_overwrite: pending harvester_local_overwrite: creators_idrefppn harvester_local_overwrite: creators_halaffid harvester_local_overwrite: publisher harvester_local_overwrite: pagerange harvester_local_overwrite: hal_id harvester_local_overwrite: hal_version harvester_local_overwrite: hal_url harvester_local_overwrite: hal_passwd harvester_local_overwrite: creators_name oai_lastmod: 2023-05-26T11:38:35Z oai_set: tse site: ut1 hal_id: hal-03364139 hal_passwd: ?yjhax hal_version: 1 hal_url: https://hal.archives-ouvertes.fr/hal-03364139 citation: Garcia, Angela, Finch, Caleb Ellicott , Gatz, Margaret, Kraft, Thomas S., Eid Rodriguez, Daniel, Cummings, Daniel, Charifson, Mia, Buetow, Kenneth, Beheim, Bret A., Allayee, Hooman, Thomas, Gregory, Stieglitz, Jonathan , Gurven, Michael, Kaplan, Hillard and Trumble, Benjamin C. (2021) APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population. eLife (10:e68231). pp. 1-20. document_url: https://publications.ut-capitole.fr/id/eprint/43846/1/68231