eprintid: 25619 rev_number: 10 eprint_status: archive userid: 1482 importid: 105 dir: disk0/00/02/56/19 datestamp: 2018-04-13 07:35:46 lastmod: 2023-09-08 08:21:49 status_changed: 2018-04-13 07:35:46 type: article metadata_visibility: show creators_name: Trumble, Benjamin C. creators_name: Stieglitz, Jonathan creators_name: Blackwell, Aaron D. creators_name: Allayee, Hooman creators_name: Beheim, Bret A. creators_name: Finch, Caleb Ellicott creators_name: Gurven, Michael creators_name: Kaplan, Hillard creators_idrefppn: 241587034 creators_idrefppn: 060256559 creators_affiliation: Institute for Advanced Study in Toulouse title: Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden ispublished: pub subjects: subjects_ECO abstract: The apolipoprotein E4 (E4) allele is present worldwide, despite its associations with higher risk of cardiovascular morbidity, accelerated cognitive decline during aging, and Alzheimer’s disease (AD). The E4 allele is especially prevalent in some tropical regions with a high parasite burden. Equatorial populations also face a potential dual burden of high E4 prevalence combined with parasitic infections that can also reduce cognitive performance. We examined the interactions of E4, parasite burden, and cognitive performance in a traditional, nonindustrialized population of Amazonian forager-horticulturalists (N = 372) to test whether E4 protects against cognitive decline in environments with a heavy pathogen burden. Contrary to observations in industrial populations, older adult E4 carriers with high parasite burdens either maintained or showed slight improvements in cognitive performance, whereas non-E4 carriers with a high parasite burden showed reduced cognitive performance. Being an E4 carrier is the strongest risk factor to date of AD and cognitive decline in industrial populations, it is associated with greater cognitive performance in individuals facing a high parasite and pathogen load, suggesting advantages to the E4 allele under certain environmental conditions. The current mismatch between postindustrial hygienic lifestyles and active parasite-rich environs may be critical for understanding genetic risk for cognitive aging. date: 2017-04 date_type: published publisher: Federation of American societies for experimental biology id_number: 10.1096/fj.201601084R official_url: http://tse-fr.eu/pub/31507 faculty: tse divisions: tse language: en has_fulltext: FALSE doi: 10.1096/fj.201601084R view_date_year: 2017 full_text_status: none publication: FASEB Journal volume: 31 pagerange: 1508-1515 refereed: TRUE issn: 0892-6638 oai_identifier: oai:tse-fr.eu:31507 harvester_local_overwrite: issn harvester_local_overwrite: faculty harvester_local_overwrite: publisher harvester_local_overwrite: creators_affiliation harvester_local_overwrite: id_number harvester_local_overwrite: doi harvester_local_overwrite: creators_idrefppn harvester_local_overwrite: creators_name harvester_local_overwrite: pending oai_lastmod: 2017-11-20T10:51:05Z oai_set: tse site: ut1 citation: Trumble, Benjamin C., Stieglitz, Jonathan , Blackwell, Aaron D., Allayee, Hooman, Beheim, Bret A., Finch, Caleb Ellicott , Gurven, Michael and Kaplan, Hillard (2017) Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden. FASEB Journal, 31. pp. 1508-1515.